MAT Overview

Metabolic Activation Therapy (MAT) is a weekly treatment in which ten carefully measured, timed pulses of insulin are delivered to a patient through a pump over a one-hour period. He or she receives three treatments within the course of the day, with a one-hour rest period between them. The procedure is safe, with no serious adverse reactions reported in more than 40,000 treatments.

MAT is performed in a physician’s office or hospital outpatient setting. A patient arrives fasting, without administering a morning insulin dose. A technician starts a small IV, and the patient breathes for a couple of minutes into a tube connected to a metabolic measurement cart to provide a baseline respiratory quotient.

After a physician determines a baseline blood sugar measurement as well, the patient ingests glucose, and his or her IV is connected to the Bionica MD-110 pump. The physician then programs the number and duration of the pulses to be delivered according to the individual patient’s weight, metabolic measurements, and the insulin concentration in the syringe.

Throughout the treatments, the physician monitors blood sugar and respiratory quotients to ensure that the patient does not become hypoglycemic, and that he or she is responding properly with a metabolic shift from fat to primarily carbohydrate. After treatment, the physician discharges the patient, instructing him or her to take a normal insulin injection and then eat a meal. Patients continue to follow their normal schedules of insulin injections, although some find they can reduce the dosages.

All the patients undergoing the therapy at ADTC have reported less fatigue, increased energy levels, and improvement in the number and severity of side effects.